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Tuesday, September 12, 2017

Cytoprotective Potential of Rutin and Quercetin in Swiss Mice Exposed to Gamma Radiation

Shrikant L. Patil1*, Tanhaji Ghodke2, Shilpa M. Patil3, Swaroop K4, H. M. Somashekarappa5
1Assistant Professor, Department of Physiology, K. S. Hegde Medical Academy, Nitte University, Mangalore, India
2Junior Research Fellow, Department of Biophysics, Govt. Institute of Science, Aurangabad, India       
3Assistant Professor, Department of Biophysics, University of Mumbai, Kalina Campus, Mumbai India       
4Centre for Application of Radioisotopes and Radiation Technology, USIC, Mangalore University, Mangalore, India
5Centre for Application of Radioisotopes and Radiation Technology, USIC, Mangalore University, Mangalore, India
 *Address for Correspondence: Dr. Shrikant L. Patil, Asst. Professor, Department of Physiology, K. S. Hegde Medical Academy, Nitte University, Mangalore, India

ABSTRACT- Radioprotective mechanisms of Rutin (RUT) and Quercetin (QRT) against gamma radiation was studied by investigating recovery of histopathology of intestinal mucosa and bone marrow in Swiss albino mice. These mice were treated with RUT (10mg/kg.b.wt.) and QRT (20mg/kg.b.wt.) once daily for five consecutive days and exposed to 7.5 Gy of gamma radiation after the last administration. RUT and QRT treatment before exposure to 7.5 Gy of gamma radiation. To assess the intestinal and bone marrow protective potential of RUT and QRT, histological analysis was carried out by observing the villus height, crypt survival, number of goblet cells/villus section and dead cells/villus section in the mouse jejunum and bone marrow cellularity at 24 hours post-irradiation. Mice exposed gamma radiation caused a significant decline in the villus height and crypt number with an increase in goblet and dead cell number with a significant decrease in bone marrow nucleated cells. The potent antioxidant nature of RUT and QRT mitigate the oxidative stress induced by gamma radiation and thus protect the mice from gastrointestinal damage.

Key-words- Rutin, Quercetin, Cytoprotective, Irradiation