Anti-cancer Activity of Leaf Extract Preparation from Ipomoea sepiaria against PC-3 Cell Line

Sudhakar Meesala1*, Satyanarayana Rentala2, DSVGK Kaladhar3
1Research scholar, Department of Biotechnology, Jawaharlal Nehru Technological University Hyderabad, India
2Associate Professor, Department of Biotechnology, GITAM University, Visakhapatnam, India
3Associate Professor, Dept. of Microbiology and Bioinformatics, Bilaspur University, Bilaspur, India
 *Address for Correspondence: Mr. Sudhakar Meesala, Research scholar, Department of Biotechnology, JNTUH, Hyderabad, India

ABSTRACT- Researches on PC-3 human prostate cancer cell lines control are needed in the present decades. The anticancer activity of aqueous extract of Ipomoea sepiaria was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay using PC-3 cell line. The present experimentation was showed that aqueous extract of Ipomoea sepiaria, when subjected to different concentrations on PC-3 cells showed IC50 cell inhibition at about 5µM for 48 hours and about 2µM for 72 hours. PTEN interacts with other expression proteins like Jun proto-oncogene, V-akt murine thymoma viral oncogene homolog 1 and 2, Tumor protein p53, Phosphatidylinositol-4,5-bisphosphate 3-kinase, etc. The present experiment shown that the leaf extract may involve in protein suppressor mechanism for PTEN in controlling of prostate cancer.

Key-words- PC-3, Ipomoea sepiaria, Anticancer activity, MTT assay, Prostate cancer

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